Archangels were a commonplace subject for artists from the Middle Ages through the Renaissance Period.  As angels who played a pivotal role in many biblical stories, the four Archangels - Gabriel, Uriel, Raphael and Michael were prominent in religious lore of Christianity, Juadaism and Islam, though mentioned very little in the canonical Gospels.  

The most famed of the Archangel Michael resides in the Santa Maria della Concezione, in the first chael.  The work is from Renaissance painter Guido Reni, who favored the high-Baroque style which evolved from the Roman Catholic Churches edict that religious art should appeal to the common man with drama and emotion. Reni's The Archangel Michael shows the androgynous angel standing above Satan, his foot firmly planted on the devil's head forcing him to the ground.  This is a scene from the Book of Revelations where Archangel Michael commands an Angel Army against Lucifer and binds him for 1000 years. The painting is often referred to as Archangel Michael Slaying the Devil.

God's Messenger Gabriel was the angel who announced to the Virgin Mary that she would have a son by God.  This biblical event is referred to as The Annunciation and is a frequent subject of Renaissance art.  Two works stand out as iconic paintings on the subject.  Da Vinci's the Annunciation was painted from 1472-1475 and is credited to both Da Vinci and his mentor Andrea del Verrocchio.  The painting depicts Archangel Gabriel kneeling  before Mary, a Madonna lily in hand to symbolize Mary's virginity.  

The Cestello Annunciation by Botticelli, commissioned in 1489, shows the same Annunciaton event with similar themes.  The painting is noted for its use of perspective in the tiles that lead the eye to the landscape.  Botticelli paints Gabriel with mouth agape, to represent his words from the Gospel of Luke which were added into the paintings original frame.  Today both paintings can be seen in the Uffizi Gallery in Florence, Italy.  

The angel Raphael was most often painted as the guardian of Tobias, son of Tobit on his journey to recover hidden money for his blind father, a passage from the Book of Tobit.  His role as protector and god of healing is emphasized in these paintings that show him leading the boy by his hand.  Filippino Lippi's version of Tobias and the Angel can be seen at the National Gallery of Art in Washington D.C.  The Book of Tobit became a popular subject for Rembrandt, who embraced the story of the pious family challenged by adversity and assisted by the Archangel Raphael.

Da Vinci created two nearly identical paintings titled Virgin of the Rocks or Madonna of the Rocks.  The painting depict a moment where the baby Jesus encounters his cousin John the Baptist as an infant.  In the paintings, the Archangel Uriel is seated to the Mary's left holding the baby Jesus.  Subtle variations can be seen in Da Vinci's two works.  In the version that hangs in the Lourve Uriel points at John.  In the version of the painting exhibited in the National Gallery in London, Mary, Jesus and John are haloed. Dan' Brown's Da Vinci Code has brought controversy to these two paintings in the name of fiction, yet - art historians surmise that the original where Uriel points at John who is closest to Mary did create confusion and the second painting by Da Vinci removed this gesture.